Linker相关论文
Antibody-drug conjugates(ADCs)are gradually revolutionizing clinical cancer therapy.The antibody-drug conjugate linker m......
Nanocarriers delivering prodrugs are important strategies to improve the in vivo effectiveness and efficiency.For therap......
A Single Chain Antibody using LoxP511 as the Linker Enables Large-Content Phage Library Construction
To obtain natural or "me-better" antibodies (e.g., affinity-maturated antibodies), phage display libraries are widely ......
Von Willebrand factor(VWF)is a concatameric plasma glycoprotein with multiple functions in hemostasis and thrombosis.Ele......
近年来基因工程抗体技术发展迅速,将单价小分子抗体改建为双价或多价,成为抗体工程中活跃的领域之一.四价抗体相比于单价或双价抗......
AIM To develop the single chain variable fragment ofMG_7 murine anti-human gastric cancer monoclonalantibody using the ......
Synthesis, bioactivity and functional evaluation of linker-modified allatostatin analogs as potentia
Insect growth regulators play an important role in integrated pest management strategies.The FGLa–allatostatins(ASTs)ar......
Five new diacid amides of di-cholesteryl L-glycinates were designed and prepared.The compounds with linkers containing 0......
Preparation and Characterization of a Novel Hybrid Copolymer Hydrogel with Poly(ethylene glycol) Dim
This paper describes the fabrication,characterization and properties of a novel hybrid poly(ethylene glycol)(PEG) based ......
To investigate the effect of spatial configuration on the gelation properties of low molecular mass gelators(LMMGs),four......
Synthetic materials that can specifically recognize proteins will find wide application in many fields.In this report,bo......
吡咯-咪唑聚酰胺是一类人工合成的能够在B-DNA小沟特异性识别碱基序列的有机小分子,并且能通过细胞膜进入细胞,调控基因的表达。它......
The assembly of metal ions Zn2+, Co2+ and H2E2Ge2O3 ligand under mild hydro- thermal conditions leads to a mixed 3D tran......
金属器官的框架(MOF ) 薄电影是在厚度从纳米到测微计的多层的材料，身体上或化学上粘合剂到一(functionalized ) 底层并且在一个理......
We have developed an expedient approach,“HOPE”(hybrid orthogonal protocol with ease) strategy for the synthesis of pep......
Synthesis and cytotoxic activities of a series of novel N-methylbisindolylmaleimide amino acid ester
A series of novel N-methylbisindolylmaleimides and natural amino acid conjugates were synthesized and evaluated for thei......
A novel 1,2,3-triazolyl-containing ligand(H2L) with long donor arms extending from the central pyridyl linker was synthe......
A convenient and efficient protocol for the synthesis of unnatural N-glycosyl a-amino acids was developed.Condensation o......
Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a heter
Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesio......
Purification and Properties of an Extracellular Polyhydroxybutyrate Depolymerase from Pseudomonas me
An extracellular polyhydroxybutyrate(PHB) depolymerase was purified to homogeneity from the culture supernatant of a PHB......
TMSOTf-catalyzed intramolecular seleno-arylation of tethered alkenes:A novel method for the solid-ph
TMSOTf-catalyzed intramolecular seleno-arylation of tethered alkenes was performed using polystyrene-supported succinimi......
Screened atrazine-mineralizing bacterium―Pseudomonas W4 was embedded inside an improved PVA- H3BO3 embedment matrix to ......
Study of action mechanisms and properties of Cr~(3+) cross-linked polymer solution with high salinit
Performance characteristics of partially hydrolyzed polyacrylamide (HPAM) and cross-linked polymer (CLP, Cr 3+ as the cr......
A new cadmium(II) coordination polymer with unique structure was synthesized under diffusion process by employing triang......
Synthesis and Applications of Tetra- functional Branched Poly(ethylene glycol) Derivative for the De
To investigate the effects of polyethylene glycol cross-linking on the mechanical properties, 80 porcine aortic valves w......
Chemical cross-linking provides an effective avenue to reduce the conformational entropy of polypeptide chains and hence......
Molecularly imprinted polymer for pre-concentration of esculetin from tobacco followed by the UPLC a
Molecularly imprinted polymers(MIPs)for solid-phase extraction and pre-concentration of esculetin have been successfully......
Synthesis of Glutathione Imprinted Polymer Particles via Controlled Living Radical Precipitation Pol
A general protocol was described for fabricating uniform molecularly imprinted polymer(MIP) particles via controlled liv......
Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR
We described herein structure-based design,synthesis and evaluation of conformationally constrained,cyclic peptidomimeti......
In this paper,a series of peptide-siRNA conjugates with phosphodiester unit as the linker targeting to Cdc2 gene were sy......
SYNTHESIS AND CHARACTERISTICS OF A CHELATING RESIN AS AN EXTRACTANT AND CHROMOGENIC REAGENT OF HEAVY
A new chelating resin (CPS-DMA-SABA) was synthesized with the chloromethylated cross-linked polystyrene porous beads (CP......
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In this work,a monomer with double bond was introduced to the surface of clay nanosheets via inclusion complexation betw......
3D-QSAR and docking studies on 2-arylbenzoxazole and linker-Y transthyretin amyloidogenesis inhibito
Transthyretin(TTR),a plasma protein with a tetramer structure,could form amyloid fibril associated with several human di......
A novel colorimetric and ratiometric NIR fluorescent sensor for glutathione based on dicyanomethylen
Glutathione(GSH)plays a critical role in maintaining oxidation-reduction homeostasis in biological systems.Considering t......
One concept for immune therapy of cancer involves induction of antigen mimic antibodies to trigger the immune response a......
A Cu(Ⅱ) Coordination Polymer with 5-Tert-butyl Isophthalate Linker:Synthesis,Crystal Structure,and M
A new Cu(Ⅱ) metal-organic coordination polymer,{[Cu2(tbip)2(bie)2]-H2O}n(1,H2 tbip = 5-tert-butyl isophthalic acid,bie ......
Discovery and synthesis of N~2,N~4-substitued-cycloalkyl[d]pyrimidine-2,4-diamine analogs: The first
A series of novel, cycloalkyl-modified pazopanib analogs 2 and 3 were designed and synthesized. Their kinase modulatory ......
Impact of the flexibility of pillar linkers on the structure and CO_2 adsorption property of ‘‘pilla
A new metal–organic framework {[Zn_2(bpta)(bpy-ee)(H_2O)_2]·x solve}_n(1)(H_4bpta = biphenyl-2,20,6,60-tetracarboxylic......
Hydrothermal Syntheses,Crystal Structures,and Characterization of Two Zinc(Ⅱ) Complexes Containing F
Two zinc(Ⅱ) complexes, namely, [Zn(L_1)Cl_2]_2(1) and {[Zn(L_2)(tbta)]·3H_2O}n(2)(L_1 = 1,3-bis(2-methylbenzimidazol-1......
Synthesis of cleavable multi-functional mikto-arm star polymer by RAFT polymerization: example of an
Multi-functional mikto-arm star polymers containing three different arms[hydrophilic,SN-38-P(OEGMA8?9)11,cationizable,SN......
α烯烃是一种独特的微生物天然产物.由P450脂肪酸脱羧酶催化的中长链(C_(12)-C_(20))脂肪酸脱羧反应生成的α烯烃因其在生物燃料和......
The relationships between solar flare parameters (total importance, time duration, flare index, and flux) and sunspot ac......
Differences in PLP-dependent cysteinyl processing lead to diverse S-functionalization of lincosamide
Subject Code:B02With the support of the National Natural Science Foundation of China and the Chinese Academy of Sciences......
Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A_4
A series of novel 1,2,3-benzotriazin-4-one derivatives were designed,synthesized and their inhibitory activities against......
DMAKO-05,a novel dimethylation of alkannin oxime derivative,exhibits remarkable anticancer activity as well as excellent......
By combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,......
Zirconium-containing UiO-66 as an efficient and reusable catalyst for transesterification of triglyc
Zirconium-based MOFs of the UiO family have attracted considerable attention due to their high thermal,chemical and mech......
A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in hu
Objective:To investigate the multienzyine complex formation of human malaria parasite Plasmodium falciparum[P.falciparum......
